Abstract
BackgroundTo determine if obstructive sleep apnea (OSA) is a risk factor for early stent thrombosis (EST; within 30 days) after percutaneous coronary intervention (PCI).MethodsThis case–control study involved 23 patients with angiographically confirmed EST after PCI (case group) and 92 PCI patients (control group) who did not develop stent thrombosis during a 2-year follow-up. Patients with symptoms and characteristics consistent with OSA (hereinafter referred to as OSA) were identified using the Berlin questionnaire, and the general characteristics of the patients and their treatments as well as outcomes were recorded. The odds ratios (ORs) for OSA were calculated. Additionally, the association between OSA and EST in patients with different conventional cardiovascular risk factors was analyzed.ResultsThe crude OR for OSA was 4.17 (95% confidence interval [CI]: 1.60–10.84, P = 0.003). After adjusting for other risk factors of EST, the OR for OSA remained significant. In participants with no or one conventional cardiovascular disease risk factor, we found a significant association between OSA and EST (OR: 17.00, 95% CI: 2.33–124.19, P = 0.005).ConclusionOSA is an independent risk factor for EST. This conclusion was further supported by the finding that in patients with few conventional cardiovascular risk factors, the contribution of OSA to EST was more obvious.
Highlights
To determine if obstructive sleep apnea (OSA) is a risk factor for early stent thrombosis (EST; within 30 days) after percutaneous coronary intervention (PCI)
In participants with no conventional risk factor or only one conventional risk factor, we found a significant association between OSA and EST (OR: 17.00, 95% CI: 2.33–124.19, P = 0.005)
We found that 60.87% of patients with EST had OSA, which was significantly higher than the rate in the control group (23.09%) as well as that reported in the literature (48.3% or 57%) [19, 20]
Summary
To determine if obstructive sleep apnea (OSA) is a risk factor for early stent thrombosis (EST; within 30 days) after percutaneous coronary intervention (PCI). The prevalence of OSA in patients with cardiovascular diseases has been reported to be 46% [3], while in patients undergoing PCI. A recent prospective study [9] reported that OSA was associated with an increase in the rate of major adverse cardiac events (MACE) in patients who had undergone coronary stenting. Considering the above reports, we hypothesized that OSA may be a risk factor for EST after PCI. We, conducted this case–control study to determine the association between OSA and EST in patients undergoing PCI
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
