Abstract
Aim . To evaluate the gender characteristics, educational level, cardiovascular diseases (CVD) risk factors and adherence to drug treatment in patients with premature CVD in an outpatient prospective registerу. Material and methods . 3690 patients with hypertension, coronary artery disease, chronic heart failure, atrial fibrillation and their combinations were enrolled in the RECVASA registry in Ryazan region of Russia. Groups of patients with early development of CVD (criterion 1 – the age of 18-49 years old, criterion 2 – the age of men 18-54 years old and women – 18-64 years old) were compared with the corresponding older groups. The gender characteristics, educational level, CVD risk factors, and adherence to drug treatment were analyzed. Results . According to criterion 1, the age groups of 18-49 years old and ≥50 years old included 347 (9.4%) and 3343 (90.6%) patients, respectively, 144 (41.5%) and 902 (27, 0%), respectively were men, p 5 mmol/L) was diagnosed significantly less frequently in patients with early development of CVD than in the older age group (47.8 vs 54.6%; p=0.047); these differences were obtained due to women (46.9 vs 58.8%; p=0.008), the proportion of individuals with hypercholesterolemia did not significantly differ among men. According to criterion 2, statistically significant differences in the frequency of hypercholesterolemia were not detected among both men and women. There was no differences in the incidence of family history (FH) of premature CVD in the study groups, while the proportion of patients with FH of premature CVD was significantly higher in men <55 years old than in women <65 years old (44.8 vs 37.7%; p<0.0001). According to criterion 1 the proportion of patients with low adherence to treatment was higher in patients with early development of CVD than in the older age group (57.1% vs 46.1%; p=0.0006), the proportion of patients with high adherence was 22.9% and 32.4% (p=0.0013), respectively. According to criterion 2, there were no differences in adherence to treatment. Conclusions . According to RECVASA registry, patients with early development of CVD were more likely to be men, in accordance with criterion 1. Patients with early development of CVD, including men and women, according to both criteria, were characterized by a significantly higher proportion of individuals with higher education and a higher proportion of smokers. In patients with early development of CVD using criterion 1, in contrast to criterion 2, hypercholesterolemia was diagnosed significantly less often than in the older age group. It is preferable to use criterion 1 to assess hypercholesterolemia in patients with early development of CVD. The proportion of individuals with FH of premature CVD was significantly higher in men <55 years old than in women <65 years old. Patients with early development of CVD according to criterion 1 were characterized by a lower adherence to drug treatment. Individuals with early development of CVD, especially <50 years old are the target group for comprehensive prevention, not only due to improving the quality of proven effective drug therapy, but also by correcting risk factors and increasing level of adherence to treatment.
Highlights
Елена Юрьевна Андреенко1*, Михаил Михайлович Лукьянов1, Сергей Степанович Якушин2, Александр Николаевич Воробьев2, Кристина Геннадьевна Переверзева2, Валерия Александровна Диндикова1, Анна Николаевна Маковеева1, Егор Викторович Кудряшов1, Сергей Анатольевич Бойцов3, Оксана Михайловна Драпкина1
Уровень образования, факторы риска и приверженность к медикаментозному лечению у больных с ранним развитием сердечно-сосудистых заболеваний (ССЗ) в рамках амбулаторного проспективного регистра
According to criterion 2, the proportion of men in the group of patients with early development of cardiovascular diseases (CVD), was 2.2 times lower, than in the older age group (18.6% vs 41.5%, respectively; p
Summary
Елена Юрьевна Андреенко1*, Михаил Михайлович Лукьянов1, Сергей Степанович Якушин2, Александр Николаевич Воробьев2, Кристина Геннадьевна Переверзева2, Валерия Александровна Диндикова1, Анна Николаевна Маковеева1, Егор Викторович Кудряшов1, Сергей Анатольевич Бойцов3, Оксана Михайловна Драпкина1. У больных с ранними ССЗ гиперхолестеринемия (>5 ммоль/л) диагностировалась значимо реже, чем в более старшей возрастной группе при использовании критерия 1 (47,8 и 54,6%; p=0,047), данные различия получены за счет женщин (46,9 и 58,8%; p=0,008), а среди мужчин доли лиц с гиперхолестеринемией значимо не отличались.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have