Patients With Mood Disorders Require Higher Doses of Buprenorphine for Management of Opiate Use Disorder [35Q

Abstract

INTRODUCTION: The purpose of this study is to compare differences in buprenorphine doses needed to treat Opiate Use Disorder (OUD) in patients with and without mood disorders. METHODS: This is a retrospective cohort study of pregnant women treated at Indiana University with OUD. IRB approval was obtained from Indiana University School of Medicine. Charts were obtained via prescription medication search. Patients were included if they had at least one outpatient visit with our center during pregnancy and delivered within the Indiana University Health system. Charts were reviewed for maternal demographics, medical history, prescription use, and delivery data. RESULTS: 266 patients were treated and 171 patients had a mood disorder: 148 with depression, 130 with anxiety, and 19 with post-traumatic stress disorder (PTSD). Over 40% of the patients had a history of dual diagnoses. Patients with a history of depression or anxiety required a higher dose of buprenorphine during pregnancy (p=0.0217, p=0.0165) compared to those without a history of mood disorder. There was no significant difference in dose in those with PTSD versus those without mood disorder. In those with a diagnosis of mood disorder, there was no difference in buprenorphine dose between women on medication versus those not on medication for depression, anxiety, and PTSD. CONCLUSION: Patients with a mood disorder require higher doses of buprenorphine compared to patients without a mood disorder. Treatment of depression, anxiety or PTSD did not show a difference in buprenorphine dose versus no treatment when a mood disorder was diagnosed.