Abstract
Cervical carcinoma has been included in the preventable diseases category ever since the use of cervical cytology in routine practice. The Pap test is an efficient screening test. We aimed to compare the cervical cytology diagnosis with biopsy and smear follow up results in our institution. We aimed to compare the diagnosis of cytology material examined in our institution during the 2009-2012 period with their biopsy and smear follow ups. The diagnoses were compared with the follow up smears and/or cervical biopsies. 13610 Pap tests were examined during September 2009-July 2012. Among these cases, there were 370 atypical squamous cells of undetermined significance (ASCUS), 29 atypical squamous cells-high grade intraepithelial lesions cannot be excluded (ASC-H), 155 low grade squamous intraepithelial lesion (LSIL), 33 high grade squamous intraepithelial lesion (HSIL), and 5 atypical glandular cell (AGC) diagnoses. The ratio of atypical squamous cell (ASCUS and ASC-H) to squamous intraepithelial lesions was 2.12. Squamous intraepithelial lesion was verified in 47 of 91 ASCUS cases. Among patients who had a cervical biopsy, 52 of 64 LSIL cases and all of the 21 HSIL cases had biopsy-proven SIL. Atypical squamous cell (ASC) is the most common diagnosis in abnormal cervical cytology. As it is indefinite, ASC is used as a quality assurance parameter and the aim is to decrease its use. As the ratio of epithelial cell abnormality is variable in different populations, the ASC/SIL is a more definite variable to be used for quality assurance. The efficiency in clinical use of the cervical cytology screening test is determined by biopsy verification. Our epithelial cell abnormality, ASC/SIL ratio and cytology-histology correlation values were parallel to the literature, proving that the methods are used reliably at our institution.
Highlights
MATERIAL and METHODCervical cytology has played a major role in reducing deaths due to cervical cancer in countries where screening programs have been used properly from the beginning.cervical cancer is still a major cause of death in countries where there are no regular screening programs.The incidence of cervical cancer is 6.6/100.000 in the United States and an estimated 12,200 new cases and 4,210 deaths due to the disorder are reported annually [1]
As the ratio of epithelial cell abnormality is variable in different populations, the Atypical squamous cell (ASC)/squamous intraepithelial lesion (SIL) is a more definite variable to be used for quality assurance
The efficiency in clinical use of the cervical cytology screening test is determined by biopsy verification
Summary
MATERIAL and METHODCervical cytology has played a major role in reducing deaths due to cervical cancer in countries where screening programs have been used properly from the beginning.cervical cancer is still a major cause of death in countries where there are no regular screening programs.The incidence of cervical cancer is 6.6/100.000 in the United States and an estimated 12,200 new cases and 4,210 deaths due to the disorder are reported annually [1]. Cervical cytology has played a major role in reducing deaths due to cervical cancer in countries where screening programs have been used properly from the beginning. Cervical cancer is still a major cause of death in countries where there are no regular screening programs. The incidence of cervical cancer is 6.6/100.000 in the United States and an estimated 12,200 new cases and 4,210 deaths due to the disorder are reported annually [1]. It takes 8th place among women’s cancers and the incidence is 4.2/100.000 in Turkey according to Globocan 2008 [2].
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