Abstract
Purpose High-normal blood pressure has been suggested to associate with target organ damage and higher left ventricular mass index (LVMI). Our aim is to find the association between people with high-normal blood pressure and their left ventricular mass index. Materials and Methods Given a total of 181 people with office blood pressure, 24-hour ambulatory blood pressure monitoring, 35 of them are normotensive (BP < 130/85 mm Hg), and 146 people with high-normal blood pressure (BP 130–139/85–89 mm Hg), divide the high-normal blood pressure group into dipper and nondipper according to their ABPM in 24 hours. All of them were performed with echocardiography to calculate LVMI. Results After adjusting for potential confounding factors, mean systolic blood pressure (BP) of the nondipper group is (119 + 9) mmHg in 24 h, which is significantly higher (p < 0.05) than in the dipper group (116 + 11) mmHg, indicating the mean systolic BP is associated with the dipper type (p < 0.05); furthermore, the higher nocturnal blood pressure is associated with the nondipper group significantly (p < 0.05), and LVMI ((121 ± 11) g/m2) of the nondipper group is also significantly higher than in the dipper group's LVMI ((108 ± 12) g/m2) (p < 0.05). The multivariate linear regression analyses revealed significant and independent associations of LVMI with these factors: triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL-C), and coefficient of variation of systolic and diastolic blood pressure in 24 hours. Conclusion After multiple relevant clinical confounding factors were adjusted, patients with dipper and nondipper high-normal blood pressure had higher LVMI. Abnormalities in circadian blood pressure variability may be associated with the left ventricular hypertrophy.
Highlights
According to the 2020 international hypertension guideline, high-normal blood pressure was defined as systolic BP between 130 and 139 mmHg and/or diastolic BP between 85 and 89 mmHg based on 2 or more properly measured seated BP readings on each of 2 or more office visits [1]
We aimed to find the relation between left ventricular mass index (LVMI) and highnormal blood pressure in both dipper and nondipper through analysis of high-normal blood pressure and normotensive by ambulatory blood pressure monitoring (ABPM)
Chronic kidney disease, coronary artery disease, peripheral artery disease, heart failure, previous stroke, and unwilling to provide written informed consent. 181 people (146 highnormal blood pressure and 35 normotensive) who were eligible to the above condition and exclusive criteria were enrolled. en, according to the results of ABPM, the highnormal blood pressure group could be divided into the dipper group (n 77) and nondipper group (n 69)
Summary
According to the 2020 international hypertension guideline, high-normal blood pressure was defined as systolic BP between 130 and 139 mmHg and/or diastolic BP between 85 and 89 mmHg based on 2 or more properly measured seated BP readings on each of 2 or more office visits [1]. Report from Yuli indicated that high-normal blood pressure has increased the risk of cardiovascular disease after adjusting for multiple factors even in low range; it is harmful to end-stage renal disease or chronic kidney disease, fundus lesion, and endothelia cell abnormality [2]. Ere is less investigation on the impact of high-normal BP on LV mechanics or left ventricular hypertrophy through ABPM. 24-hour ambulatory blood pressure monitoring (ABPM) was recommended to apply for the prevention, evaluation, detection, and treatment of both highnormal blood pressure and hypertension in patients [3]. ere is less investigation on the impact of high-normal BP on LV mechanics or left ventricular hypertrophy through ABPM.
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