Patients with a high estradiol: oocyte ratio have compromised clinical outcomes

Abstract

OBJECTIVE: The objective of this study was to determine the effect of the estradiol per oocyte ratio after controlled ovarian hyperstimulation on implantation, clinical pregnancy and birth rates.DESIGN: Retrospective analysis of data collected from January 2002 through December 2007. Patients were divided into four treatment groups based on the level of estradiol per oocyte collected at retrieval. Clinical and laboratory end points were analyzed using Fisher's exact test and t-test as appropriate.MATERIALS AND METHODS: Patients (n=4398) ≤37 years old undergoing IVF/ICSI were used in this study. Serum estradiol (pg/mL) was measured on the day of hCG. Donor oocytes, epididymal or testicular sperm and patients with no embryos transferred were excluded.Table 1Effect of estradiol: oocyte ratio on clinical outcomes.E2:Oocyte RatioNAvg. Days StimulationAvg. # EmbryosClinical Pregnancy (%)Birth Rate (%)Implantation Rate (%)<10042510.12.1265 (62)¤Different character symbols within columns indicate significant differences (p<0.05).245 (58)¤Different character symbols within columns indicate significant differences (p<0.05).417 (46)¤Different character symbols within columns indicate significant differences (p<0.05).100-200229910.12.21401 (61)¤Different character symbols within columns indicate significant differences (p<0.05).1274 (55)¤Different character symbols within columns indicate significant differences (p<0.05).2122 (42)¥Different character symbols within columns indicate significant differences (p<0.05).200-300116810.22.2689 (59)¤Different character symbols within columns indicate significant differences (p<0.05).¥Different character symbols within columns indicate significant differences (p<0.05).628 (54)¤Different character symbols within columns indicate significant differences (p<0.05).¥Different character symbols within columns indicate significant differences (p<0.05).1016 (39)§Different character symbols within columns indicate significant differences (p<0.05).>30050610.22.2274 (54)¥Different character symbols within columns indicate significant differences (p<0.05).248 (49)¥Different character symbols within columns indicate significant differences (p<0.05).399 (36)£Different character symbols within columns indicate significant differences (p<0.05).¤' ¥' §' £' Different character symbols within columns indicate significant differences (p<0.05). Open table in a new tab CONCLUSIONS: These results suggest that patients with a high estradiol per oocyte ratio have poorer clinical outcomes. This ratio can be used as a predictor of treatment outcome. OBJECTIVE: The objective of this study was to determine the effect of the estradiol per oocyte ratio after controlled ovarian hyperstimulation on implantation, clinical pregnancy and birth rates. DESIGN: Retrospective analysis of data collected from January 2002 through December 2007. Patients were divided into four treatment groups based on the level of estradiol per oocyte collected at retrieval. Clinical and laboratory end points were analyzed using Fisher's exact test and t-test as appropriate. MATERIALS AND METHODS: Patients (n=4398) ≤37 years old undergoing IVF/ICSI were used in this study. Serum estradiol (pg/mL) was measured on the day of hCG. Donor oocytes, epididymal or testicular sperm and patients with no embryos transferred were excluded. CONCLUSIONS: These results suggest that patients with a high estradiol per oocyte ratio have poorer clinical outcomes. This ratio can be used as a predictor of treatment outcome.