Abstract
BackgroundSevere fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SFTSV) infection, with a rapidly progressive central nervous system (CNS) disturbance, in Dongyang, Zhejiang Province, China, in 2017.Case presentationA 64-year-old man was admitted to hospital after 4 days of fever. SFTSV was detected 1 day after the patient was admitted to hospital. The patient presented with CNS disturbance and died 4 days after admission. Detailed clinical and epidemiological investigations and laboratory tests were conducted. Reduced platelet, white blood cell, lymphocyte, and neutrophil counts, elevated lactate dehydrogenase, creatine kinase, aspartate aminotransferaseand alanine aminotransferase concentrations, and an increased activated partial thromboplastin time were observed. In a phylogenetic analysis, the isolate clustered close to a strain derived from South Korea.Conclusions: This is the first case of SFTSV infection with CNS disturbance in Dongyang, Zhejiang Province, China. The surveillance of suspected cases of SFTS is important in SFTSV endemic regions.
Highlights
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011
Here, we have reported a patient with Severe fever with thrombocytopenia syndrome virus (SFTSV) infection accompanied by central nervous system (CNS) disturbance in Dongyang, Zhejiang Province, China, in 2017
SFTSV-associated CNS disturbance has been observed, but little information is available on the clinical manifestations, epidemiology, and characteristics of the virus [6, 18]
Summary
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging hemorrhagic fever that was first described in China in 2011. We report a patient who died of Severe fever with thrombocytopenia syndrome virus (SFTSV) infection, with a rapidly progressive central nervous system (CNS) disturbance, in Dongyang, Zhejiang Province, China, in 2017. Conclusions: This is the first case of SFTSV infection with CNS disturbance in Dongyang, Zhejiang Province, China. Several studies have reported patients who presented with rapidly progressive disturbances of the central nervous system (CNS), such as a human-. Diagnosed encephalitis was defined as a condition meeting the following criteria: (a) sudden onset; (b) symptoms of fever, headache, vomiting, etc.; and (c) disorders of consciousness, which have been previously described [6, 8].
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