Abstract
The evaluation of the liver structure can be done through invasive and non-invasive imaging methods. Noninvasive methods include abdominal ultrasound, transient hepatic elastography (Fibroscan). biomarkers such as hyaluronic acid (HA), alpha-2 macroglobulin, laminin, fibronectin, Fibroindex or panels such as Fibrotest-actiTest. Liver biopsy, the most invasive method of assessing the structure of the liver and the lesions present, is still indicated in certain reserved cases, when the diagnosis remains uncertain despite all the investigations. Antiviral therapy in Romania for hepatitis B virus includes the administration of pegylated interferon alfa 2a and various nucleoside/nucleotide analogs (ANN): adefovir, entecavir, tenofovir, lamivudine. IFNα is the most effective antiviral treatment in children, regarding the seroconversion of Hbe Ag to anti Hbe Ac and the disappearance of Hbs Ag. Sustained response is defined as maintaining the response to treatment for at least 6 months after its discontinuation.
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