Abstract
interferon-gamma and IL-6 were significantly higher in cases. In the logistic regression model, adjusting by age, sex and duration of diabetes, an increased risk was observed in the highest serum values tertile of V-CAM (OR 11.31; 95%CI 5.6–22.9) E-selectin (OR 2.90; 95%CI 1.5–5.4), IL-6 (OR 8.11; 95%CI 3.6–18.4) and resistin (OR 1.85; 95%CI 1.0–3.5). A dose–response effect was observed with these inflammatory markers. No relation was observed between silent myocardial ischemia and metabolic control parameters. Discussion: Inflammation plays a major role in atherosclerosis and coronary heart disease, particularly in the context of diabetes. The appreciation of the role of inflammation in silent myocardial ischemia in diabetes, provides insights into its pathogenesis, and offers opportunities for diagnosis and prediction of this subclinical and early manifestation of coronary artery disease, a major complication in type 2 diabetes.
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