Abstract
Topical treatment is the mainstay for mild or moderate psoriasis, but patients are generally little satisfied. Calcipotriol/betamethasone dipropionate (Cal/BD) cutaneous foam has shown to improve signs and symptoms in plaque psoriasis patients. This study assessed patient's satisfaction with Cal/BD foam in a real‐life Italian dermatological clinical practice. A multicenter, 4‐week observational prospective cohort study enrolled, in 17 Italian dermatology clinics, adult patients with plaque psoriasis on the body and/or scalp. Treatment satisfaction was assessed by 9‐item Treatment Satisfaction Questionnaire for Medication (TSQM‐9), preference over previous treatments by Patient Preference Questionnaire (PPQ), and change in disease state by Psoriasis Area Severity Index (PASI). Overall 256 patients were eligible, with a mean (SD) age of 55.6 (15.4) years, 59.4% were males. Psoriasis severity was mild in 52.0% of patients, moderate in 43.3%, and severe in 4.7%. Scalp involvement was present in 36.7% of patients. Previous antipsoriatic treatments had been received by 80.5% of patients. TSQM‐9 median (25th–75th percentile) scores were 83.3 (66.7–88.9) for effectiveness, 77.8 (66.7–88.9) for convenience, and 78.6 (64.3–92.9) for global satisfaction. Mean (SD) PASI value decreased from 7.3 (4.8) to 2.1 (2.7) after 4 weeks. More than 90% of patients previously treated for psoriasis evaluated the Cal/BD foam more effective, easier to use and better tolerated compared to previous topical treatments at PPQ. This observational study provides real‐life evidence of a high level of satisfaction with effectiveness and convenience of the Cal/BD foam in a cohort of plaque psoriasis patients, with an objective improvement in PASI.
Highlights
Psoriasis is a common chronic inflammatory multisystem disease with a strong genetic predisposition and an immune pathogenetic component.[1,2,3] Approximately 90% of patients affected with psoriasis have plaque psoriasis.[4]
More than 90% of patients previously treated for psoriasis evaluated the Calcipotriol/betamethasone dipropionate (Cal/betamethasone dipropionate (BD)) foam more effective, easier to use and better tolerated compared to previous topical treatments at Patient Preference Questionnaire (PPQ)
First-line management of mild or moderate plaque psoriasis consists of topical treatments[20]; they are associated with lower adherence rates than systemic treatments, which represents a major issue for treatment effectiveness.[21]
Summary
Psoriasis is a common chronic inflammatory multisystem disease with a strong genetic predisposition and an immune pathogenetic component.[1,2,3] Approximately 90% of patients affected with psoriasis have plaque psoriasis.[4]. In phase II–III studies, Cal/BD foam obtained significantly greater improvements in Psoriasis Area Severity Index (PASI), Dermatology Life-Quality Index (DLQI), and total clinical scores than placebo, BD topical comparators, or a gel and ointment Cal/BD formulation, with a favorable safety profile.[10,11,12,13] In the foam aerosol, the active ingredients are dissolved in volatile propellants that evaporate when the product is applied to the skin, creating a foam layer containing a supersaturation of the actives that enables a greater penetration of the drug through the epidermis This is believed to account for the higher efficacy shown by the cutaneous foam compared to the gel and ointment Cal/BD formulation.[12]. Data management activities were performed in-house by LEO Pharma according to their standard operating procedures
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