Abstract
e19554 Background: Idelalisib, a selective oral inhibitor of PI3Kδ, demonstrated considerable anti-tumor activity in patients with relapsed/refractory iNHL in a phase 2 trial (Gopal, 2014). The purpose of this analysis was to evaluate patient-reported outcomes (PRO) data to determine whether drug treatment was associated with a change in health-related quality of life (HRQL). Methods: Eligible iNHL patients (pts) were refractory to both rituximab and an alkylating agent. Idelalisib 150 mg PO BID was administered continuously until disease progression. HRQL was measured by the 42-item Functional Assessment of Cancer Therapy-Lymphoma (FACT-Lym), comprising FACT-G subscales: Physical Well-being (PWB), Social/Family Well-being (SWB), Emotional Well-being (EWB), Functional Well-being (FWB), and the Lymphoma Subscale (LymS). Trial Outcome Index (TOI) is PWB + FWB + LymS. Higher scores reflect better HRQL. Minimally important differences (MID) on the FACT-G ranged 3-7 points (2-5 points for subscales). The FACT-...
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
