Abstract
BackgroundThe clinical consequences of an antibiotic allergy label (AAL) are detrimental impacting health care delivery and patient outcomes. We assessed hospital inpatients with intent to offer free AAL assessment within a randomised controlled trial (RCT). ObjectiveTo determine the feasibility of establishing an adult antibiotic allergy delabeling service in a Western Australian tertiary public hospital. MethodsInpatients (N=1503) with AAL were identified through medical records and screened for eligibility to participate in an RCT. Those recruited were randomised to undergo assessment by skin testing +/- oral challenge, or direct oral challenge. A control group received usual care. ResultsOf the 1503 inpatients with an AAL, 429 (28.5%) were eligible for AAL assessment. The primary excluding factor (1,074, 71.5%) was contraindicated medication use (387, 36.0%), followed by cognitive impairment (298, 27.9%). Thirty-nine patients were randomised, 20 received allergy testing and 19 usual care; all patients were followed up for 5 years. Older patients were less likely to be eligible (10- year increase: OR = 0.82, 95% CI = 0.77-0.88, p<0.0001); whilst surgical patients were more likely to be eligible than medical patients (OR = 2.49, 95% CI = 1.97-3.16, p<0.0001). ConclusionsAntibiotic allergy delabeling in the acute care context is not straightforward. Competing clinical concerns and patient acceptance are some barriers to an inpatient service. Nor is it apparent that inpatient vs outpatient testing is cost saving although select patient groups may benefit. Testing younger people and those with predicted high antibiotic usage will derive maximal individual and health system benefits.
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More From: Journal of Allergy and Clinical Immunology: Global
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