Patient Perception and Experience of Laparoscopic Excision vs. Ablation of endometriosis: a crowd-sourced comparative evaluation of symptom and Quality of Life outcomes

Abstract

Study Objective: To compare laparoscopic Ablation and Excision in terms of symptom and Quality of Life outcomes as perceived by endometriosis patients. DesignA Cohort, Method comparison Questionnaire-based study SettingEndometriosis-focused Social Media site PatientsEndometriosis patients with history of Laparoscopic Ablation and Excision. InterventionsOn-line questionnaire focused on pre and post procedure (ablation and excision) outcomes across 63 measures in 5 realms: Physical Symptoms, Functional Impact, Psycho-emotional Impact, Social/Sexual Impact, Economic/Educational Impact. Measurements and Main Results232 respondents with surgical history that included laparoscopic ablation and excision (without concomitant or interposed hysterectomy) identified for ablation only physical symptom improvement of 11.3% and 8.5% for dysmenorrhea and menorrhagia respectively. Ablation provided no significant improvement in any other physical symptom measure. Excision was identified as providing improvements across all symptoms ranging from 28% to 46%.In terms of Functional Impact, ablation provided non-significant improvements or worsening of status. Excision demonstrated significant improvement for patients across most measures of Functional Impact.In terms of Psycho-emotional Impact, a worsening of QoL status is identified in 23 of 24 measures following ablation. Excision demonstrated improvement in 22 of 24 measures.For Social-Sexual Impact, ablation resulted in worsened status across all measures with excision demonstrating improvements in all measures, significantly so in most.For Economic/Educational Impact, significant worsening of measures or insignificant improvements were demonstrated following ablation. Excision demonstrated significant improvement in most measures.In all realms, pre-Excision status was worse than pre-Ablation.Allowing for a more focused comparison of ablation and excision, 113 respondents with a surgical history of ablation sequentially followed by excision demonstrated outcomes similar to the larger group: overall worsening of status resulting from ablation and overall improvement in status following excision with pre-Excision morbidity higher than pre-Ablation. ConclusionIn this cohort of patients undergoing laparoscopic endometriosis excision after having undergone endometriosis ablation, the former demonstrated greater beneficial effect over a broad spectrum of symptom and QoL measures.