Abstract
Aim:This case–control study examined the impact of diabetes mellitus (DM) on survival in lung cancer patients and lung cancer on glycemic control in DM.Materials & methods:Patients with a new lung cancer diagnosis and DM (n = 124) were matched to 124 lung cancer patients without DM. Laboratory results and DM and cancer therapies were obtained from electronic records.Results:Five-year overall survival for lung cancer patients with and without DM was 20 versus 29% (p = .12). Glycemic control among DM patients did not change significantly with time.Conclusion:DM does not cause adverse impact on lung cancer survival. Lung cancer does not affect glycemic control.
Highlights
Summary points r Impact of lung cancer or its treatment on diabetes mellitus (DM) and the impact of DM on lung cancer survival are unknown on an individual level. r DM patients had a significantly higher BMI (p < .001). r Significant differences in glucose within 1 year of cancer diagnosis were seen between groups in sex and in use of corticosteroids, chemotherapy, targeted therapy and radiation therapy. r Among patients with DM, the mean hemoglobin A1c was 7.0% within 1 year of cancer diagnosis. r In Kaplan–Meier survival analysis, 5-year overall survival was estimated at 20% for DM patients versus 29% for patients without DM
The hazard ratio for matched pairs was 1.37 (95% confidence interval: 0.91–2.02). r Five-year progression-free survival was estimated at 21% for DM patients versus 22% for patients without DM
The hazard ratio for matched pairs was 1.33 (95% confidence interval: 0.89–1.97). r Mean hemoglobin A1c and glucose values among diabetes mellitus (DM) cases did not change significantly over time. r Mean glucose level among DM patients was significantly higher than for patients without DM (p < .001)
Summary
This case–control study examined the impact of diabetes mellitus (DM) on survival in lung cancer patients and lung cancer on glycemic control in DM. Lay abstract: The objective of this study was to identify the effect of diabetes mellitus (DM) on survival of lung cancer patients and to determine whether lung cancer and its treatment affect glycemic control
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