Abstract
Introduction:Patient and public involvement (PPI) aims to improve the quality, relevance, and appropriateness of research and ensure that it meets the needs and expectations of those affected by particular conditions to the greatest possible degree. The evidence base for the positive impact of PPI on clinical research continues to grow, but the role of PPI in preclinical research (an umbrella term encompassing 'basic', 'fundamental', 'translational' or 'lab-based' research) remains limited. As funding bodies and policymakers continue to increase emphasis on the relevance of PPI to preclinical research, it is timely to map the PPI literature to support preclinical researchers involving the public, patients, or other service users in their research. Therefore, the aim of this scoping review is to explore the literature on patient and public involvement in preclinical research from any discipline. Methods: This scoping review will search the literature in Medline (PubMed), Embase, CINAHL, PsycINFO, Web of Science Core Collection, Scopus, and OpenGrey.net to explore the application of PPI in preclinical research. This review will follow the Joanna Briggs Institute (JBI) guidelines for scoping reviews. It will be reported according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR). Two reviewers will independently review articles for inclusion in the final review. Data extraction will be guided by the research questions. The PPI advisory panel will then collaboratively identify themes in the extracted data. Discussion: This scoping review will provide a map of current evidence surrounding preclinical PPI, and identify the body of literature on this topic, which has not been comprehensively reviewed to date. Findings will inform ongoing work of the research team, support the work of other preclinical researchers aiming to include PPI in their own research, and identify knowledge and practice gaps. Areas for future research will be identified.
Highlights
Patient and public involvement (PPI) aims to improve the quality, relevance, and appropriateness of research and ensure that it meets the needs and expectations of those affected by particular conditions to the greatest possible degree
The rationale for how findings are presented and changes adopted through involvement of the PPI Advisory Panel will be described fully in the final scoping review manuscript
The extracted data will be presented at the available Advisory Panel Meeting and the team will identify key themes both for the Spinal Cord Repair Project and more generally for PPI in preclinical research. These findings will inform the development of the project PPI strategy, the scoping review manuscript, and a report aiming to make the findings accessible to preclinical researchers and PPI contributors
Summary
Eligible literature will be identified through searching the following databases: Medline (PubMed), PsycInfo, Embase, CINAHL, Web of Science Core Collection, Scopus, and OpenGrey.net This range of database was chosen for inclusion due to the broad nature of the review question. This review will be carried out in accordance with the JBI Framework for conducting a scoping review[26], which builds upon the guidelines of Arksey and O’Malley and Levac[28,29] These principles will be followed during the study selection process, starting with a review of titles and abstracts using the inclusion and exclusion criteria, followed by full text retrieval of potentially eligible studies to be further examined for eligibility. The following elements will be extracted from the selected studies: 1. Author(s)
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