Abstract
IntroductionThe aim of this study is to evaluate adherence and persistence of patients treated with Imatinib, Nilotinib or Dasatinib, also giving economic evaluations on therapy costs for Received Daily Dose (RDD).Materials and MethodsIn this retrospective study, we took into account 3 years from 1st Jan. 2009 to 31st March.2012. Treatment adherence was quantified utilizing ratio between RDD and PDD (Prescribed Daily Dose). Persistence is reckoned taking into account the actual therapy days, comparing posology with supplied dose, drawing the graph using Kaplan-Meir method.ResultsAdherence results in values between 0.8 and 1.0 for Nilotinib (Adh = 0.93), Imatinib (Adh = 0.83) and Dasatinib (0.85). Imatinib has better persistence, 90% of patients in treatment exceed one year of treatment versus 83.3% for Nilotinib and 80% for Dasatinib. The cost per single day of treatment (cost per RDD) was € 39.41 for Imatinib, € 113.60 for Nilotinib and € 94.84 for Dasatinib.ConclusionPatients with CML have a loose of adherence both in first line with Imatinib and in second line of therapy with Dasatinib and Nilotinib. Loss of adherence remains a big problem and could be minimized by a patient-oriented project invlolving physicians, nurses, pharmacists and caregiver.
Highlights
The aim of this study is to evaluate adherence and persistence of patients treated with Imatinib, Nilotinib or Dasatinib, giving economic evaluations on therapy costs for Received Daily Dose (RDD)
Adherence results in values between 0.8 and 1.0 for Nilotinib (Adh = 0.93), Imatinib (Adh = 0.83) and Dasatinib (0.85)
The study includes three oral chemotherapeutic agents used for Chronic Myeloid Leukemia (CML): Imatinib, Nilotinib and Dasatinib, suggesting a new method to evaluate adherence, as this parameter is of great bearing in successfulness of treatment, and of persistence with drug until patient’s death or progression of pathology or toxicity of therapy
Summary
The aim of this study is to evaluate adherence and persistence of patients treated with Imatinib, Nilotinib or Dasatinib, giving economic evaluations on therapy costs for Received Daily Dose (RDD). [12] The aim of this study was to monitor adherence and persistence to oral chemotherapy with the aid of a single patient-oriented application program, taking into account drug used parameters as Received Daily Dose (RDD) and Prescribed Daily Dose (PDD). The study includes three oral chemotherapeutic agents used for CML: Imatinib, Nilotinib and Dasatinib, suggesting a new method to evaluate adherence, as this parameter is of great bearing in successfulness of treatment, and of persistence with drug until patient’s death or progression of pathology or toxicity of therapy
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