Abstract
BackgroundDespite the overwhelming prevalence and health implications of obesity, it is rarely adequately addressed in a health care setting. PATHWEIGH is a pragmatic approach to weight management that uses tools built into the electronic medical record to overcome barriers and guide care. Implementation strategies are employed to facilitate adoption and use of the PATHWEIGH tools and processes. The current study will compare the effectiveness of PATHWEIGH versus standard of care (SOC) on patient weight loss in primary care and explore factors for its successful implementation.MethodsA stepped wedge cluster randomized trial design will be used within an effectiveness-implementation hybrid study. Adult patient weight loss and weight loss maintenance will be compared in PATHWEIGH versus SOC in 57 family and internal medicine clinics in a large health system in Colorado, USA. Effectiveness will be evaluated using generalized linear mixed models to determine statistical differences in weight loss and weight loss maintenance at 6, 12, and 18 months. Patient-, provider-, and clinic-level predictors will be identified using mediator and moderator analyses. Conceptually guided by the Practical, Robust, Implementation and Sustainability Model (PRISM), a mixed methods approach including quantitative (practice surveys, use tracking) and qualitative (interviews, observations) data collection will be used to determine factors impeding and facilitating adoption, implementation, and maintenance of PATHWEIGH and evaluate specified implementation strategies. A cost analysis of the practice and system costs and resources required by PATHWEIGH relative to the reimbursement collected will be performed.DiscussionThe effectiveness and implementation of PATHWEIGH, and their interrelatedness, for patient weight loss are collectively the focus of the current trial. Findings from this study are expected to serve as a blueprint for available and effective weight management in primary care medical practice.Trial registrationClinicalTrials.govNCT04678752. Registered on December 21, 2020.
Highlights
Despite the overwhelming prevalence and health implications of obesity, it is rarely adequately addressed in a health care setting
The primary analysis is expected to provide a conservative estimate of the treatment effect, and we propose the following secondary analyses to assess the treatment effect in alternative cohorts
This study should provide findings that will be applicable to many settings and will be examined in a large number of diverse practices, this study will only be implemented in a single health system in one state
Summary
Despite the overwhelming prevalence and health implications of obesity, it is rarely adequately addressed in a health care setting. PATHWEIGH is a pragmatic approach to weight management that uses tools built into the electronic medical record to overcome barriers and guide care. In the USA, obesity prevalence continues to increase. Obesity is a wellestablished risk factor for numerous diseases, including diabetes, cardiovascular disease, cancer, immobility, mental health issues, as well as all-cause mortality [2]. Obesity is a strong and independent risk factor for poor outcomes due to COVID-19 [3]. Obesity is being increasingly recognized as a risk factor for disease, but a disease unto itself [2]. Obesity is rarely addressed in a healthcare setting. ~ 50% of people with a BMI of 50 kg/m2 (considered morbid or extreme obesity) have a documented diagnosis of obesity [5] and < 1% of people with any degree of overweight or obesity are offered anything other than lifestyle advice [6]
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