Abstract
Quarters of guinea-pig adrenals were incubated in the presence of radioactive pregnenolone and progesterone (bearing different labels) and doubly labelled progesterone, 17-hydroxyprogesterone, corticosterone and Cortisol were isolated from the incubates. The pregnenolone isotope/progesterone isotope ratios in these compounds were then used to interpret the operative pathways for the formation of corticosteroids. These experiments were done under three different conditions: (1) the two C-21 steroid substrates were made isomolar before incubation, (2) the substrates were non-isomolar and (3) preinéubated adrenal tissue was used. Under all the three conditions it was observed that in the guinea-pig adrenals progesterone may not be an obligatory intermediate for corticosterone biosynthesis, Further, cortisol has seen to be formed by a pathway bypassing both progesterone and 17-hydroxyprogesterone.
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