Pathotypic and phylogenetic studies of urine Escherichia coli isolates from girls <5 years of age in Marvdasht hospital

Abstract

Background: Urinary tract infection includes infection of the kidneys and bladder. Escherichia coli is the most known cause of urinary tract infection. Severity of the infection depends on the host sensitivity and the presence of virulence factors in the bacterium. In this study, antibiotic-resistance patterns and phylogenetic grouping of urine E. coli isolates from girls referred to Shahid Motahari Hospital, Marvdasht, Iran, were investigated. Methods: In this sectional-descriptive study, urine samples of 45 girls under the age of five suspected to urinary tract infection were collected in a period of 3 months. Eleven isolates of E. coli were identified using common morphological and biochemical tests. Antibiotic resistance patterns of isolates were identified. Phylogenetic groups were determined using polymerase chain reaction methods. Results: In this study, the most antibiotic resistance of the isolates was against cephalexin and the least antibiotic resistance was against imipenem (IPM). Besides, all isolates belonged to the phylogenic Group D. Conclusion: Results shows that IPM may be high effective to treat of the patients referred to Shahid Motahari Hospital in Marvdasht. Overall, results of antibiotics susceptibility tests in different area may be different. Therefore, different antibiotics are required to administrate for patients in different regions around the world or even in a country.