PATHOPHYSIOLOGY OF PLASMIN SYSTEM. V. PLASMIN SYSTEM AND POSTPARTUM HEMORRHAGE.

Abstract

As to the etiological determination of atone uterine bleeding, the following results were obtained by the measurement of plasmin system. 1. Both caseinolytic and fibrinolytic activity of euglobulin fraction and antitryptic activity of plasma gradually increased during physiological pregnancy and reached a maximum at the time of labor. 2. The plasma of patients with atonic uterine bleeding and patients with hypofibrinogenemia showed significantly elevated caseinolytic activity of euglobuhzi fraction and decreased antitryptic activity. 3. Positive fibrinolysis in plasma was found in 13 of 180 (7.2%) cases of normal and abnormal parturient women, and 5 of these 13 positive cases had atone uterine bleeding. From the above experiments, we suggest that significant proportion of cases of atonic uterine bleeding includes mild or latent or pre-fibrinogenopenia and the difference between atone uterine bleeding and fibrinogenopenia may be not qualitative but only quantitative. The term ‘atonic uterine bleeding’ may be applied not only in cases with myoatony but also in those of vasculo-atony and coagWo-aatony.