Abstract
Aldosterone is a mineralocorticoid produced in zona glomerulosa cells of the adrenal cortex, and its secretion is stimulated by high plasma K+ concentrations (hyperkalemia) and angiotensin II. Both factors lead to membrane depolarization, followed by an increase of cytosolic Ca2+, which ultimately triggers the aldosterone production. Autonomous production of aldosterone, called primary aldosteronism (PA), is found in 10% of patients with essential hypertension of which one third have aldosterone producing adenomas (APAs). In 5 – 6% of APAs somatic mutations of the alpha subunit (ATP1A1) of the Na+/K+ ATPase have been identified. This study aimed at investigating the effects of mutants of ATP1A1 on intracellular Ca2+ and pH homeostasis in adrenocortical cells.
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