Abstract
In healthy articular cartilage, the extracellular matrix (ECM) is properly maintained by the overall anabolic and catabolic balance of slow synthesis and degradation, a so-called homeostatic state, under the influence of synovial metabolism. Though the ECM of articular cartilage tissue contains low amounts of hyaluronan (HA), its main components are collagen, type II, IX, and XI, and proteoglycans, such as aggrecan. Nevertheless, HA plays crucial roles in cartilage, especially in retaining aggrecan in tissues.
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