Abstract
Rare anemias encompass a large and markedly heterogeneous group of nearly 90 different conditions [...]
Highlights
Commission, have a global prevalence of less than 5 per 10,000 indi- hemolysis bear oxidative properties that may cause myocardial and viduals
Heart disease is the outcome of three main factors, the anemia u itself with its consequences, the particular features and mechanisms l related to the underlying molecular defect and the applied therapy. ia Chronic anemia causes tissue hypoxia, which in turn motivates a number of compensatory reactions, including high output state that rc may lead to heart failure when anemia is prolonged and severe
High output heart failure was the main cause of death in e patients with thalassemia major, the most severe clinical form of betathalassemia, before regular blood transfusion therapy was established m in late 1960s
Summary
Commission, have a global prevalence of less than 5 per 10,000 indi- hemolysis bear oxidative properties that may cause myocardial and viduals. Due to their extremely low prevalence, many of the rare anemias are sis of the abnormal hemoglobin S causes deformation of erythrocytes poorly understood. Owever, these conditions share some basic features, such as anemia, hemolysis and red blood cell defects that contribute significantly to the development of cardiovascular complicaly tions.
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