Abstract
Abstract : The disease syndromes produced by both Bacillus anthracis organisms and by sterile in vitro toxins are orderly and predictable. Most of the signs and changes in the blood cellular, and gaseous elements occur late in the septicemic phase of disease, whereas similar changes occur earlier after administration of toxins. The only pathophysiological responses peculiar to any of the three species of animals used in this study, the rhesus monkey, chimpanzee, and rabbit, was the presence of nucleated red blood cells in the rabbit and the absence of these cells in the two primates. All effects appear to be nonspecific and include evaluation of white blood count with a marked shift to the lift, decreased Ca2+, Na+, and cholinesterase with increased K-, Cl-, and HPO4(2-). Hyperesthesia frequently was observed, and late in the course of disease a terminal hypoglycemia with alkalosis and hypoxia occurred. One of the most significant observations was failure of the body to respond to the organisms per se but rather to the toxins of B. anthracis. (Author)
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