Pathophysiology Manifestations of SARS-CoV-2: A Comprehensive Review

Abstract

Coronaviruses (CoVs) are wrapped up positive-sense RNA viruses, classified by Club-like spikes that stretch across the surface and follow exceptionally large RNA genomes and unique amplification mechanisms. The diseases caused by coronaviruses in animals and birds range from potentially fatal respiratory infections in humans to enteritis in pigs, cattle, and poultry with upper respiratory illnesses. Here, we provide a short overview of viruses, including their morphology, categorization, mechanisms of replication, and pathogenicity, particularly in humans, as well as the most recent approaches to COVID-19 prevention and therapy. We have presented the pandemic virus relationships with pathophysiological human conditions like blood group cases and age group mortality, the effect on men's fertility and obstetricians in pregnant women, and also address the outbreaks greatly pathogenic SARS-CoV (“Severe Acute Respiratory Syndrome Coronavirus”) &MERS-CoV (“Middle East Respiratory Syndrome”) recently reported. The novel coronavirus disease (COVID-19) is a pandemic cause for the whole world so its scientific data or information will be beneficial for the research and development in the recent scenario as well as for future perspective.