Abstract
Pathophysiological roles of cytokine-chemokine immune network.
Highlights
Hwang summarizes the current state of knowledge regarding the molecular mechanisms that underlie the multiple roles played by T-bet in T helper cell development and finemodulation of IL-2 production in Th1 cells
Excessive and/or inappropriate production and actions of cytokines and chemokines are involved in the pathogenesis of infection, inflammation, allergy, autoimmune diseases, and immunerelated diseases, such as diabetes, atherosclerosis, rheumatic arthritis, and cancer
suppressor of cytokine signaling 1 (SOCS1) may be important in the pathogenesis of systemic lupus erythematosus through Treg plasticity, because SOCS1-deficient T cells induce lupus-like autoimmunity [3]
Summary
Hwang summarizes the current state of knowledge regarding the molecular mechanisms that underlie the multiple roles played by T-bet in T helper cell development and finemodulation of IL-2 production in Th1 cells. Cytokines and chemokines exert crucial roles in the development, homeostasis, activation, differentiation, regulation, and functions of innate and adaptive immunity. Excessive and/or inappropriate production and actions of cytokines and chemokines are involved in the pathogenesis of infection, inflammation, allergy, autoimmune diseases, and immunerelated diseases, such as diabetes, atherosclerosis, rheumatic arthritis, and cancer.
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