Abstract
Pathophysiological Effect of Oxygen Free Radicals on Mobility and DNA Integrity of Human Seminal Spermatozoa
Highlights
Oxidative stress is a known cause of male infertility, mostly because of its effect on sperm motility and DNA integrity of sperm
Great production of Reactive oxygen species (ROS) is located in seminal leukocytes and morphologically abnormal spermatozoids
Clinical implications are different in cases where the ROS sources are seminal leukocytes and in pathological cases where the sperm cells themselves are the source of ROS production
Summary
Oxidative stress is a known cause of male infertility, mostly because of its effect on sperm motility and DNA integrity of sperm. The oxygen is necessary to maintain physiologic and metabolic balance of sperm cells, but free oxygen radicals can compromise functionality and vitality of sperms [2]. These molecules are very unstable, shortly-lived and very reactive and they ‘’steal’’ electrons from other structures to reach ground state and in that way they are changing structure of the cell [3]. Clinical implications are different in cases where the ROS sources are seminal leukocytes and in pathological cases where the sperm cells themselves are the source of ROS production. Most of the antioxidant enzymes of the sperm are lost during the process of spermiogenesis and sperm is present for long period of time in genital tracts of male and women, which makes it more susceptible to the ROS induced damage [7]
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