Pathomorphosis of Uterine Myomas in Women

Abstract

Taking stroma (ECM-extracellular matrix) and not tumour parenchyma as a criterion of categorization, the tu- mours can be divided into two groups, i.e. those which produce stroma (non-epithelial malignant tumours) or sarcomas and the tumours which take advantage of the local tissue stroma (malignant epithelial tumours) or carcinomas. Involve- ment of stroma is noted also within the reciprocal relationship between stroma and tumour cells, which has been described in detail on the example of uterine myoma. ECM also collaborates with CAM (cell adhesion molecules), particularly in development of neoplastic metastases. Pathomorphosis of myomas, myosarcomas and of stromal uterine tumours was described with particular attention given to differential diagnosis and the resulting clinic predictive and prognostic implications. A probable mechanism of neopla- sia based on dissipative structures of cells was presented and introduction of a disoric zone of a tumour, i.e. of a marginal zone between the tumour and the morphologically normal tissue was suggested. The zone seems extremely important in prediction and prognosis related to relapse and/or tumour metastases.