Abstract
The article considers the pathomorphological studies of the effect of vaginal suppositories "Melanizol" on the irritative vaginitis caused by a mixture of turpentine and dimethylsulfoxide in rats. Vaginal suppositories "Melanizol" showed a therapeutic effect on the vaginitis, which manifested by preventive the occurrence of necrotic-inflammatory lesions, and promoted the healing of defects in mucosal and submucosal layer of the vaginal wall. Low positive therapeutic effect of suppositories "Gravagin" on the state of the vaginal wall of female rats on the model of experimental vaginitis has been proven. Sufficiently large foci of destruction of the vaginal wall, foci of inflammation, edema of collagen fibers of rats vaginal wall of this group was present. Vaginal suppositories "Melanizol" are perspective for using as a drug for the treatment of nonspecific vaginitis with destructive reaction and inflammation.
Highlights
Infectious-pelvic inflammatory disease is an urgent medical and social issue of Obstetrics and Gynecology [1, 3, 8]
Animals were divided into groups: 1-st group – intact animals, 2-nd group – control pathology, 3 group – animals treated with vaginal suppositories “Melanizol”, 4 group – animals treated with the comparator vaginal suppositories “Gravagin”; 5 group – animals treated with suppository base in the equivalent amount
Closer to the muscle layer is changed in the submucosal layer, which looked like loose connective tissue
Summary
Infectious-pelvic inflammatory disease is an urgent medical and social issue of Obstetrics and Gynecology [1, 3, 8]. Despite the fact that they do not result in high mortality rates, these infections are associated with high levels of anxiety and reduced quality of life [11] and is the cause of most outpatient gynecologic visits. Metronidazole is antibacterial drugs with anti-anaerobic activity effective for the treatment of vaginal infections. It is known that the metronidazole can be used effectively in various forms for treatment of vaginal infections. In most cases the topical treatment of vaginal infections is as effective as oral treatment that results in a study the impact of new vaginal suppositories “Melanyzol” [5] based on metronidazole and tea tree oil on morphological status vaginal mucosa against the background of the experimental irritative vaginitis is very interested.
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