Abstract
Introduction: Partial molar trophoblast degeneration is a benign disease characterised by numerous complications such as an invasive mole and malignant alteration.Methods: This was a retrospective study which recruited 70 pregnant women diagnosed with hydatidiform mole or with physiological pregnancy spontaneously aborted. The pregnant women had similar demographic features and were included in two groups. 35 pregnant women with a molar pregnancy diagnosed during the first trimester were included in the study group; while 35 pregnant women with miscarriages during the fi rst trimester were included in the control group.Results: Examined trophoblast changes were: type of atypia, amount and mass of trophoblast proliferation. Specifi c β HCG serum levels were observed in all pregnant women before the treatment. Pregnantwomen in the study group had statistically signifi cant higher levels of β HCG serum in comparison with the control group (both average levels 60191.37±49662.75 and levels according to gestational age). Statisticallysignifi cant changes of villous trophoblast were observed by the pathomorphological analysis: mild trophoblast atypia (57.14%); pronounced trophoblast mass (45.71%) and mild trophoblast proliferationamount (51.43%).Conclusion: Serum β-HCG level measurements and pathomorphological analysis of chorionic villi are reliable and effective methods in a partial mole diagnostics.
Highlights
Partial molar trophoblast degeneration is a benign disease characterised by numerous complications such as an invasive mole and malignant alteration
Hydatidiform mole is a condition characterized by trophoblast tissue altered into numerous and al
290 cases of pathological trophoblast a year per 300 000 births and miscarriages were reported in Croatia [4]. 1.5 cases of the gestational trophoblastic disease per 1000 births was reported during a seven-year-period at the Department of Gynaecology and Obstetrics, Clinical Centre Serbia [5]
Summary
Partial molar trophoblast degeneration is a benign disease characterised by numerous complications such as an invasive mole and malignant alteration. Hydatidiform mole is a condition characterized by trophoblast tissue altered into numerous and al-. Based on differences in morphology, histopathology, karyotype and clinical features, hydatidiform mole can be categorized into partial and complete. A complete mole (55%-75% of all molar pregnancies) is characterized by hydropically degenerated villi, absence of embryo and amniotic sac. A partial mole (25%-45% of all molar pregnancies) is characterized by a partial degeneration of villi while trophoblast proliferation is focally pronounced [2]. 1.5 cases of the gestational trophoblastic disease per 1000 births was reported during a seven-year-period at the Department of Gynaecology and Obstetrics, Clinical Centre Serbia [5]. The incidence of gestational trophoblastic disease cannot be precisely reported since there is neither a register of disease nor a disease specific program and management protocol
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