Abstract
Results The PNX resulted in a rapid and marked loss of cancellous bone volume (8 ± 1% versus 14 ± 2%, mean ± SD, p<0.005) and profoundly disrupted trabecular structure with increases in dynamic formative parameters, such as mineralizing surface, mineralization apposition rate and adjusted appositional rate. In the chondro-osseous junction, activated osteoclasts phagocitized degenerating chondrocytes, leaving a minimal amount of cartilage matrix and activated osteoblasts, thus losing their scaffolding for bone formation directly covering the hypertrophic zone cells. The osteoid surface and thickness in the chondro-osseous junction were significantly increased in PNX chickens (43 ± 14 % versus 12 ± 6 % and 4 ± 0.2μm versus 3 ± 0.4 μm). In the subjacent cartilage regions being protected from further resorption, abundant labeled cartilage remained with higher cellularity.
Highlights
From 10th International Conference on Conservative Management of Spinal Deformities - SOSORT 2013 Annual Meeting Chicago, IL, USA. 8-11 May 2013
Pathomechanism underlying the onset of scoliosis in a PNX broiler chicken model Yoichi Aota*, Hayato Terayama, Tomoyuki Saito, Masahiro Itoh
It is known that fast-growing birds have a unique paradigm of rapid bone elongation with minimal metaphyseal bone production
Summary
Pathomechanism underlying the onset of scoliosis in a PNX broiler chicken model Yoichi Aota*, Hayato Terayama, Tomoyuki Saito, Masahiro Itoh. From 10th International Conference on Conservative Management of Spinal Deformities - SOSORT 2013 Annual Meeting Chicago, IL, USA. Purpose The pinealectomy (PNX) in a chicken model consistently induces scoliosis with anatomic features that are similar to human adolescent idiopathic scoliosis (AIS). This experimental study attempted to improve the understanding of the mechanisms underlying the onset of scoliosis in a PNX broiler chicken model
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