Abstract
Background: Lipid metabolism may impact disability in people with multiple sclerosis (pwMS). Methods: Fifty-one pwMS entered an ultrasound and MRI study, of whom19 had followed a pathology-supported genetic testingprogram for more than10years (pwMS-ON). Genetic variation, blood biochemistry, vascular blood flow velocities, diet and exercise were investigated. Results: pwMS-ON had significantly lower (p<0.01) disability(Expanded Disability Status Scale) than pwMS not on the program (1.91±0.75 vs 3.87±2.32). A genetic variant in the lipid transporterFABP2 gene (rs1799883; 2445G>A, A54T) was significantly associated (p<0.01) with disability in pwMS not on the program, but not in pwMS-ON (p=0.88). Vascular blood flow velocities were lower in the presence of the A-allele. Conclusion: Pathology-supported genetic testingmay provide guidance for lifestyle interventions with a significant impact on improved disability in pwMS.
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