Abstract
To understand the progression of porcine epidemic diarrhea virus infection, we inoculated gnotobiotic pigs with a newly emerged US strain, PC21A, of the virus. At 24–48 hours postinoculation, the pigs exhibited severe diarrhea and vomiting, fecal shedding, viremia, and severe atrophic enteritis. These findings confirm that strain PC21A is highly enteropathogenic.
Highlights
To understand the progression of porcine epidemic diarrhea virus infection, we inoculated gnotobiotic pigs with a newly emerged US strain, PC21A, of the virus
To understand the progression of porcine epidemic diarrhea virus (PEDV) infection, we studied the pathogenesis of the newly emerged US strain, PC21A
PEDV strain PC21A was detected in the sample by reverse transcription PCR (RT-PCR) selective for the nucleocapsid gene (229–557 nt)
Summary
To understand the progression of porcine epidemic diarrhea virus infection, we inoculated gnotobiotic pigs with a newly emerged US strain, PC21A, of the virus. To understand the progression of PEDV infection, we studied the pathogenesis of the newly emerged US strain, PC21A. PEDV strain PC21A was detected in the sample by reverse transcription PCR (RT-PCR) selective for the nucleocapsid gene (229–557 nt). Pigs 1–3 and 5 were inoculated orally and/or intranasally with 6.3–9.0 log10 genomic equivalents (GE) of PEDV strain PC21A; pig 4 was exposed to the virus by indirect contact with inoculated pig 3.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
