Abstract
The renal biopsy findings in 127 previously untreated children with the nephrotic syndrome of recent origin are reported. "Minimal changes" were observed in 98 (77%) patients, and most responded to corticosteroid therapy. In addition to the well-known forms of chronic glomerulonephritis, two distinct but less well recognised conditions are described. In one, focal sclerosing lesions involve the glomeruli to an increasing extent, and may ultimately lead to renal failure; in its early stage the condition may be difficult or even impossible to distinguish from " minimal changes ". Most cases are steroid-resistant. In the other condition there is mild mesangial thickening and proliferation similar to that observed in resolving post-streptococcal nephritis. Although some cases may be steroid-resistant and the clinical course protracted, the prognosis is generally favourable.
Published Version
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