Abstract
The acquired immunodeficiency syndrome (AIDS) is an often fatal illness characterized by a profound derangement in cell-mediated immunity (CMI), leading to multiple opportunistic infections and unusual neoplasms (10, 18, 23, 28). Epidemiologic evidence indicates that this syndrome, which was first reported in the spring of 1981 (8, 9), is transmissible sexually and by parenteral exposure to blood or blood products. Recent virologic and serologic studies suggest a causal link between AIDS and infection with an as yet unclassified retrovirus (3, 12, 21) related to the human T-lymphotropic retroviruses (20). Impaired CMI in AIDS patients is thought to be caused by infection of and reduction in the number of T-helper lymphocytes by this virus, which was first isolated from a lymph node of a homosexual man with unexplained lymphadenopathy and was tentatively called lymphadenopathy-associated virus (3).
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