Abstract
Ischemia reperfusion induced acute kidney injury (I/R AKI) by bilateral renal artery occlusion-reperfusion method in male SD rats were performed to study progressive pathological events after acute kidney injury. Serum creatinine level rose up to the level of 4–4.6 mg/dL, 24h after I/R AKI episode. Serum creatinine, urine volume, urine osmolality, urinary protein, gross pathology, histopathology and morphometry were studied at periodical interval from day 1 to day 28 after I/R AKI along with sham control group. Increased serum creatinine, decreased urine volume and urine osmolality were recorded at day 1. These changes returned to the normal level by day 7 of I/R AKI except slight increase in urine volume on day 28 of I/R AKI. Histopathological changes mainly affecting the tubules of outer stripe of medulla occasionally involving the cortex and pelvis were observed. These changes comprised complete loss of cellular detail of tubules as acute tubular necrosis followed by process of regeneration and redifferentiation in the form of tubules, which represented almost near to normal structure by day 14 of I/R AKI. However, presence of tubulo-interstitial foci on day 28 of I/R AKI with increased interstitial index and collagen fibers indicated that a portion of tubules did not recover completely and may be responsible for the further deterioration of kidney function.
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