Pathology of intractable temporal lobe epilepsy in children

Abstract

Objective To study the pathology of intractable temporal lobe epilepsy in children.Method 80 children with intractable temporal lobe epilepsy underwent anterior temporal lobe resection.All samples underwent routine histological study.All patients were followed - up from one to five years after operations.The effects of operation were evaluated with Engel class.Results The major pathological findings in these patients included:isolated hippocampal sclerosis ( n =26),benign tumors ( n =20),FCD ( n =10) and hippocampal sclerosis with other lesions ( n =9).Mter surgery,58 patients were Engel class Ⅰ,11 class Ⅱ,6 class Ⅲ and 5 class Ⅳ.Conclusions There are many pathological findings in intractable temporal lobe epilepsy in children,and hippocampal sclerosis,benign tumors and FCD are the most commonly seen.Anterior temporal lobe resection could achieve excellent seizure control.The connection between the pathological lesions and surgical effects should be paid attention for further study. Key words: Child; Epilepsy,temporal lobe; Pathology; Hippocampal sclerosis