Pathology of hepato-pancreato-biliary tumors: An overview.

Abstract

Pathology of hepato-pancreato-biliary tumors: An overview. Abstract. Malignant tumors of the hepato-pancreato-biliary organs are usually conventional adenocarcinomas, except for the liver, where they are, based on their characteristic morphology, called hepatocellular neoplasms. In addition to these pure morphological approaches, molecular and especially morphomolecular investigations have yielded many new findings in recent years, always with the aim of providing patients the best possible therapy. For example, focal nodular hyperplasia (FNH) of the liver is now considered a reactive change that does not require further therapy. On the one hand, molecular stratification of hepatocellular adenomas allows to identify high-risk tumors, and which should be surgically treated. As a further example, tumors of the extra- and intrahepatic bile ducts are differentiated today into small-duct-type and large-duct-type, which have different, therapeutically relevant, molecular profiles. The present review provides an overview of the most important and common tumors of the hepato-pancreato-biliary organs.