Pathology of Cytomegalic Inclusion Body Disease in Swine

Abstract

Ilistopathological and electron microscopical studies were performed to in-vestigate lesions in a series of eight cases (7 to 180 days of age) of porcine cytomegalicinclusion body disease (inclusion body rhinitis) encountered in several hog yards inTowada City, Aomori Prefecture. The characteristic feature noted was the formation ofintranuclear inclusion bodies in the tubuloalveolar glandular epiLhelium of the nasalmucosa. These bodies were classified into three distinct types. In four cases, intranuclearinclusion bodies were demonstrated also in various other organs throughout the body, such as the trachea, bronchioles, salivary glands, lacrimal glands, kidneys, adrenals andNymph nodes. Associated frequently with the inflammatory changes of the nasal mucosawere splenic extramedullary hematopoiesis, glomerular nephritis and nonpurulentencephalitis. Electron micrographs of the nasal mucosa demonstrated intranuclear cap-sids and enveloped particles in cytoplasmic vacuoles and in the glandular lumen.