Abstract
There were no significant histologic differences between the bladder cancers in 39 patients with normal urinary excretion of tryptophan metabolites and those in 10 patients with abnormal metabolite excretion patterns. Neither were there statistically significant differences in histology between “occupational” and “spontaneous” tumors, nor between tumors in patients who had “ever smoked” cigarettes and those who had “never smoked” cigarettes. However, in both the “occupational” and the “ever-smoked” groups, apparently greater numbers of carcinomas were either wholly or partially composed of squamous elements, and further study of this point in larger series of cases seems indicated. For such studies, case material will be needed, not only from industries in which employees have had known exposures to materials later shown to be bladder carcinogens, but from nonindustrial sources after careful direct, personal interviews have divided cases into those with possible or definite occupational exposure and those with no history of exposure to the currently known occupational carcinogens.
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