Abstract

Anyone practicing a discipline that identifies its role as "the study of disease" must resign himself to mastering a continually shrinking fraction of available information. In this Annual, the 15 articles survey an impressive range of organs, techniques, diseases, and theoretical formulations, conveying an impression of rapid but disconnected expansion in all directions. Several contributions combine results from more than one technique, affording a welcome breadth of perspective, notably the reports on black lung disease, neonatal respiratory distress, and breast diseases. Two articles on the liver and one on intraepithelial neoplasm of the uterine cervix employ the classical approach, which uses predominantly light microscopy as a tool for clinicopathologic evaluation. Three articles on electron microscopy stand more as catalogs of esoteric observations than as useful contributions to pathophysiologic insight. To the extent that trends are apparent, neoplasia and immunopathology seem to be the most popular disease categories, while the most

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