Abstract
Aim:The aim of the study was to examine pathology and the distribution pattern of Newcastle disease virus (NDV) in internal organs of chickens from a field case using immunohistochemical staining.Materials and Methods:10 groups of broiler, layer, and domestic chicken were collected from necropsy room Division of Pathology, Bogor Agricultural University. These chickens were originated from West Java and collected based on pathologist diagnosis as suspect of Newcastle disease (ND). They were subsequently confirmed positive of ND with real-time-reverse transcription polymerase chain reaction assay. The respiratory, circulatory, digestive, lymphoreticular and central nervous systems were collected for histopathology examination.Results:The gross pathology and histopathology changes were tracheitis, pneumonia, pericarditis, myocarditis, catarrhal proventriculitis, catarrhal enteritis, typhlitis, perihepatitis, pancreatitis, nephritis interstitial, splenitis, atrophy of Bursa Fabricius, and encephalitis.Conclusion:The distribution pattern of NDV in internal organs of chickens from a field case in this study is similar with a previous reported pattern in systemic cases of the internal chicken organs. High intensity of immunohistochemistry stain result was detected in trachea, lung, proventriculus, duodenum, cecal tonsil, kidney, and brain.
Highlights
Newcastle disease (ND) is an important avian disease in Indonesia
High intensity of immunohistochemistry stain result was detected in trachea, lung, proventriculus, duodenum, cecal tonsil, kidney, and brain
Newcastle disease virus (NDV) is divided into four groups, which are velogenic viscerotropic (Asian type) characterized by acute lethal infection with intestinal hemorrhage, velogenic neurotropic (America type) characterized by respiration and nerve lesion without intestinal lesion with high mortality, mesogenic characterized by respiratory and nerve lesion with low mortality, and lentogenic characterized by asymptomatic lesion in the intestine [2,3]
Summary
Newcastle disease (ND) is an important avian disease in Indonesia. ND has spread all over Indonesia and cause massive loss in poultry business. The disease is spreading rapidly, both morbidity and mortality of ND virus (NDV) infection can reach 100% which known to have infected over 200 bird species [1]. The causative agent of the disease is NDV designated as avian paramyxovirus Type-1, genus avulavirus. NDV is a part of ribonucleic acid virus with the single stranded genome and negative polarity. NDV is divided into four groups, which are velogenic viscerotropic (Asian type) characterized by acute lethal infection with intestinal hemorrhage, velogenic neurotropic (America type) characterized by respiration and nerve lesion without intestinal lesion with high mortality, mesogenic characterized by respiratory and nerve lesion with low mortality, and lentogenic characterized by asymptomatic lesion in the intestine [2,3]
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