Abstract
Biobanks are units where high quality and long-term protection of biomaterials is maintained. This system, in which biological materials and data are systematically recorded and stored, is a unique resource for the study of the pathophysiology of disease, the development of diagnostic biomarkers, and working with human tissues for the potential discovery of targeted therapeutic agents. At this point, the pathology unit plays a unifying and complementary role between the clinical and core disciplines and offers optimal management of the patients' biomaterials for diagnostic and research projects. The aim of this article is to present general information with regard to a biobank constructed for the storage of tumor tissue and blood biospecimens. Ethical issues (informed consent, protection of confidentiality and privacy, and secondary use of biospecimens) and the information technology system (collection, systematic recording, backup and protection of clinical information) are important issues in biobanking. The selection of freezers to be used in storage (mechanical freezers, liquid-vapor nitrogen tanks), and if mechanical freezers are preferred the establishment of the relevant infrastructure and support team (such as additional power units for protection from power outages), the preservation of materials by aliquoting in different freezers, ensuring financing so as to afford the cost of the infrastructure, and implementation of all these dynamics while adhering to international guidelines are of the utmost importance.
Highlights
It was during the mid-1990s that researchers began to consider collections of biospecimens as a resource for their projects [1]
The Organisation for Economic Cooperation and Development (OECD) describes biobanks as service providers and repositories of living cells, organisms, cells and tissues, and of information relating to these materials [5]
We aimed to present information related to tumor biobanking. (Turk Patoloji Derg 2020, 36:93-108)
Summary
It was during the mid-1990s that researchers began to consider collections of biospecimens as a resource for their projects [1]. A biobank is a valuable resource to access high-quality human biospecimens while preserving them over the long term. Those biospecimens may be used to elucidate the pathophysiology, diagnoses, and the treatments of diseases [2]. Tumor biobanks are basically BRCs. The Organisation for Economic Cooperation and Development (OECD) describes biobanks as service providers and repositories of living cells, organisms, cells and tissues, and of information relating to these materials [5]. Pathologists provide essential diagnostic information for the treatment of the patients and can make decisions on the sampling of tissues for the biobank as well as optimal preservation of biospecimens. We aimed to present information related to tumor biobanking
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