Abstract
This study was conducted to isolate Toxoplasma gondii from aborted placentae of ewes, & follow up the histopathological changes that produced in some different organs such as liver, brain & eyes of rats which inoculated experimentally by suspension of the parasite. Histopathological changes in brain represented by presence of tachyzoites & tissue cyst at 30/45 days post infection associated with encephalomeningitis-while in liver, the lesions characterized by presence of perivascular & periductular cuffing of tachyzoites associated with pyknotic nuclei of hepatocytes. Moreover, in the eye tachyzoites & tissue cyst has been seen invaded in extraocular muscles, congestion of blood vessels with lymphocytic infiltration and retinochoroiditis, also has been
Highlights
Toxoplasmosis is a world wide infection in man and animals caused by obligate intracellular protozoan called Toxoplasma gondii[1]
This study was conducted to fined capability of T. gondii to produce histopathological changes in albino rats, revealed after 30 days post infection (PI) crescent-shaped tachyzoit, this finding has been confirmed [9,10]
Defense mechanism in liver tissue take place by kupffer cells which appear hypertrophied in infected rats due to invasion of tachyzoites, these cells considered as phagocyte & responsible for defense mechanism against antigen, cells can secrete TNF-∝ which in turn, produce cytokines in lymphocytes as a chemotactic factors, while perivasculer cuffing of tachyzoit occurs due to requirement of parasite to oxygen and nutrient material for developing stage[14, 15]
Summary
Toxoplasmosis is a world wide infection in man and animals caused by obligate intracellular protozoan called Toxoplasma gondii[1]. Cats & other felidae are considered the final host, while rodents, reptiles, birds and other mammals including human are intermediate host[2]. The parasite causes sever economical loss implicating in reproductive failure in farm animals by foetal resorption mummification, still birth or abortion[3]. There are three infectious stages of T. gondii include tachyzoite, brachyzoite and sporozoite in oocyst[4]. The study of toxplasmosis is of medical importance due to socioeconomic impact of the disease in human suffering and the cost of care of sick childerns especially those with mental retardation and blindness are enormous. T gondii its of economic importance in veterinary public health since it is the major cause of animal abortions
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
