Pathological profile of patients with breast diseases in Shiraz.

Abbas Rezaianzadeh,Sedigheh Tahmasebi,Majid Akrami,Abdolreza Rajaeefard,Abdolrasoul Talei,Hamidreza Tabatabaee,Mojtaba Sepandi

doi:10.7314/apjcp.2014.15.19.8191

Abstract

Around 200,000 breast disorders are annually diagnosed all over the world. Fibrocystic changes are the most common breast disorder and fibroadenoma is the most prevalent benign breast tumor. The present study aimed to determine the spectrum, type and prevalence of breast masses in women referred to Shiraz University of Medical Sciences between 2004 and 2012 . A cross-sectional study was conducted on the diagnostic reports data. A total of 640 samples were studied. Most 57.3% of masses were detected in the left breast, 65%, 28.2% and 6.1% of cases presenting with benign, malignant, and inflammatory lesions, respectively. Among all the samples the most prevalent diagnosis (37.7%) was fibroadenoma and fibrocystic lesions (17%). 174 samples (96% of the malignant cases) were invasive. 6.5% of the benign, and 37% of the malignant cases occurred in post menopause women and the differences were statistically significant. Among those with malignant tumors lymph nodes were involved in 25.6% of menopausal women and 44.2% of non-menopausal ones, and the difference was statistically significant. Regular clinical breast examination beside mammographic follow-ups, especially during menopause, should be carried out as a priority and a national organized program should be designed for screening breast disorders.

Highlights

Breasts undergo various changes during puberty, pregnancy, and menopause due to hormonal changes which might result from different reasons in different countries and ethnicities
The present study was conducted on 640 samples collected from the women referring to the breast clinic of Shiraz University of Medical Sciences in order to extract and investigate epidemiological data on the prevalence of breast masses
The frequency of benign masses is higher compared to malignant ones (Caleffi et al, 2004; Pollitt and Gateley, 2004; Sirous and EBRAHIMI, 2008; Olu-Eddo and Ugiagbe, 2011)

Summary

Introduction

Breasts undergo various changes during puberty, pregnancy, and menopause due to hormonal changes which might result from different reasons in different countries and ethnicities. 1 out of every 6 women around the world undergoes biopsy due to breast problems; such a way that around 200,000 breast disorders, including inflammatory changes and malignant as well as benign lesions, are annually diagnosed all over the world. Fibrocystic changes are the most common breast disorder and fibroadenoma is the most prevalent benign breast tumor (Templeman and Hertweck MD, 2000; Hartmann et al, 2005; Degnim et al, 2007). Fibrocystic changes are the most common breast disorder and fibroadenoma is the most prevalent benign breast tumor. Conclusions: Regular clinical breast examination beside mammographic follow-ups, especially during menopause, should be carried out as a priority and a national organized program should be designed for screening breast disorders

Methods

Results

Conclusion