Abstract
The present study was designed to investigate the pathological lesions in different organs induced by chronic Ultraviolet type B (UVB) and Xylene exposure in mice. Forty mice were used in this study and divided into four groups; Group A (Control group, n=10) not exposed to UVB and Xylene, Group B (n=10) exposed to Xylene through painting the mouse’s back skin, Group C (n=10) which were exposed to UVB light only, while the remainder group (Group D, n=10) were exposed to Xylene and UVB. The dorsal skin of mice from group B and D were painted with 1ml of Xylene whereas the animals in the group C and D exposed to UVB light for 30 minutes 4 days/week (6 weeks). The result showed that Xylene exposure in group B produced chronic tracheitis, bronchitis with some degenerative lesions in the neurons and glial cells of the brain, no specific lesions were found in the liver, spleen and kidney. UVB exposure in group C caused chronic tracheitis, lesions like lobar pneumonia, bronchopneumonia, and atelectasis, cellular swelling in the liver and kidney and follicular depletion in the spleen. In group D, the lesions became more prominent when animals exposed to both Xylene and UVB. We concluded that Xylene exposure has an adverse effect in some internal organs of mice, but not to all, when combined with UVB exposure it exaggerates its adverse effects on all of the examined organs.
Highlights
In the past, the wrinkle, mottling, excrescences, and flaccidity of aging skin were considered as inevitable “natural” characters of aging
To further elucidate behavioral xylene toxicology, the current study was designed to demonstrate the pathological lesions in different organs induced by chronic Ultraviolet type B (UVB) and Xylene exposure in BALB/c mice
Mice were divided into four groups; Group A (Control group, n=10) which were not exposed to UVB and Xylene spraying, Group B (n=10) exposed to Xylene only, Group C (n=10) which were exposed to UVB light only, while the remainder group (Group D, n=10) were exposed to Xylene and UVB
Summary
The wrinkle, mottling, excrescences, and flaccidity of aging skin were considered as inevitable “natural” characters of aging. Xylene as a solvent and cleaning agent is used most commonly in histopathological laboratories, printing, painting, rubber and leather industries (Savolainen et al, 1978, Savolainen et al, 1979, Savolainen et al, 1981, Savolainen et al, 1984, Mohtashamipur et al, 1985, Richer et al, 1993, Kandyala et al, 2010). Occupational exposure to xylene may result from the use of the compound in paints, varnishes, glues and printing inks, and in the rubber and leather industries. Our previous study showed that chronic skin exposure to xylene induced epidermal hyperplasia when combined with UVB its effect were accelerated (Hassan et al, 2015). To further elucidate behavioral xylene toxicology, the current study was designed to demonstrate the pathological lesions in different organs induced by chronic UVB and Xylene exposure in BALB/c mice
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