Abstract
Objective - The effects of vasectomy on testes and related structures are disputable. The aim of this study was to determine whether the reproductive organs of rabbits were influenced after 12 months vasectomy. Study design – Bilateral vasectomy was performed on 10 male adult New Zealand Big Eared White Rabbits (another 10 rabbits set as sham operated group) and tissue samples were examined by light microscopy after 12 months treatment. The histologic alterations were observed and analyzed by stereology method. Cell apoptosis by Terminal Deoxynucleotidyl Transferase Mediated dUTP Nick End Labeling (TUNEL) assay were employed. Result - Bilateral vasectomy for 12 months affected the morphology of testis, epididymis and vas deferens tissues. Significant changes were noted in the histological stereology analysis. The apoptosis of the cells on the testis, epididymis and vas deferens increased compared with the sham operated group. Conclusion - Our findings suggest that the reproductive tissues of rabbits were influenced in a relatively longer term vasectomy.
Highlights
Vasectomy was first used as a procedure for male contraception in 1899 [1]
Study design—Bilateral vasectomy was performed on 10 male adult New Zealand Big Eared White Rabbits and tissue samples were examined by light microscopy after 12 months treatment
Our findings suggest that the reproductive tissues of rabbits were influenced in a relatively longer term vasectomy
Summary
About more than 40 million couples rely on it to prevent pregnancy over the world [2]. This operation is thought to be a convenience and high safety method. Side effects such as the stasis of epididymis, painful nodules and sperm granuloma limit the acceptability of using this technique [3]. The effect of vasectomy on testis and related organs between species are disputable. Reported that after vasectomized the rats, significant alterations of testis were observed. In the contrast of this finding, another report reported by McDonald found no changes in testis of rats [5]. There are contradictory reports regarding the short-term and long-term effect
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