Abstract
BackgroundUse a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments.MethodsIn present study, 125I seeds were implanted into spinal canal of T13 level of spine in banna mini-pigs. After operation, the pigs were raised up to 8 months, behavior changes were recorded within this period. After 8 months, spinal cords were collected for pathological analysis.ResultsIn this study, a 125I brachytherapy animal model had been successfully established, in the model group, the banna pigs' Tarlov scale decreased from 5 to 2.57 ± 0.36, significant cellular impairments were noted by pathological analysis.ConclusionsWithout any protection and operation improvement, 125I implantation can cause serious histological impairments and moving difficulty for banna mini-pigs; this present research provides an alternative tool to study spinal 125I brachytherapy.
Highlights
Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments
Aim to solve the radiation myelopathy problem, many rodent animal models had been used, the rodent is small in size compared to human and their immunology system is different from human being, which restricts the usage of this kind of animal model
Aim to mimic the actual clinical conditions, Digital subtraction angiography (DSA)guided operation was performed and 125I seeds were implanted into spinal canal in T13 level of banna minipigs
Summary
Use a banna mini-pig to set up 125I implantation model, and investigate the consequence of radiation-related impairments. 125I brachytherapy is an effective way to kill tumor cells locally and protect healthy tissues, some complications occurs, such as radiation damages to the tissue around the seeds, which may cause complications, especially radiation myelopathy [3,4] How to reduce this side effect attracted abundant effort from related medical scientists, but clinically complicate conditions restricted the progress of this kind of research. Aim to solve the radiation myelopathy problem, many rodent animal models had been used, the rodent is small in size compared to human and their immunology system is different from human being, which restricts the usage of this kind of animal model In this present study, we chose a banna-mini pig as our model animal; because it had similar body size as human and its structure of spinal cord share the similar anatomy structure with human. After raised the banna pigs up to 8 months, the pathological impairments caused by 125I were investigated and we manage to find whether their impairments share the similar character with clinical patients which receive the 125I brachytherapy
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
