Abstract
Objective: This study was undertaken to investigate the clinicopathological factors that influence the growth of a small renal mass (SRM) in patients subjected to a delayed surgery intervention. Methods: We reviewed the clinical records of 37 patients with SRM 4 cm at diagnosis, who underwent delayed surgical intervention during surveillance from January 2000 to December 2013. Radiographic evaluation using computed tomography (CT) scan, magnetic resonance imaging (MRI) were performed at least every 6 months and the tumor size was determined at least twice. Results: Histopathological analysis revealed that in 35 of the 37 patients the tumor was malignant in stage pT1aN0M0. There were 28 clear cell carcinomas and 7 non clear cell carcinomas. There was a significant difference in the time to tumor doubling (TTD) among clear cell carcinomas (p=0.033). There was also a significant difference in the tumor growth rate (mm/year) of clear cell carcinomas between male and female patients (p=0.028). Conclusion: The growth rate of small renal mass was slow in the majority of our patients. Pathological grade and gender significantly influenced the growth of clear cell carcinomas.
Highlights
Renal cell carcinoma (RCC) detection was performed using noninvasive abdominal imaging techniques, which included: ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) [1,2,3,4,5].Following a retrospective review, it was found that most small renal masses (SRMs) showed a slow growth rate and low malignant potential [6]
It was found that most small renal masses (SRMs) showed a slow growth rate and low malignant potential [6]
We found that the growth factor of SRMs was highly associated with their pathological grade [7]
Summary
Renal cell carcinoma (RCC) detection was performed using noninvasive abdominal imaging techniques, which included: ultrasonography (US), computed tomography (CT) and magnetic resonance imaging (MRI) [1,2,3,4,5]. It was found that most small renal masses (SRMs) showed a slow growth rate and low malignant potential [6]. We found that the growth factor of SRMs was highly associated with their pathological grade [7]. We investigated growth factors in a larger sample size, using the enzyme mindbomb E3 ubiquitin protein ligase 1 (MIB-1), which is strongly associated with pathological grade
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