Abstract
BackgroundPathological diagnosis based on core needle biopsy (CNB) should be different from a resected specimen because it is difficult to apply the histological criteria established for resected specimens to CNB due to sampling limitations. A pathological classification for thyroid nodule on CNB was first proposed by the Korean Group in 2015. The objective of this study was to test the reliability and clinical value of this proposal.MethodsAccording to the Korean proposal, the CNB diagnoses were categorized into unsatisfactory, benign, indeterminate, follicular neoplasm, suspicious for malignancy and malignant. A comparative study between the diagnoses of CNB and resected specimens was performed.ResultsThe consistency was moderate (κ = 0.448). Combined indeterminate, suspicious for malignancy and malignant into a single group collectively referred to as “malignant” with the remaining merged into “others”, CNB demonstrated a 95.93% sensitivity, 97.30% specificity, 62.07% accuracy, 99.81% positive predictive value (PPV) and 62.07% negative predictive value (NPV) for preoperative malignancy evaluation.ConclusionsThe Korean proposal for pathological classification of thyroid nodules on CNB is objective, operable and highly valuable.
Highlights
Pathological diagnosis based on core needle biopsy (CNB) should be different from a resected specimen because it is difficult to apply the histological criteria established for resected specimens to CNB due to sampling limitations
The biopsy techniques for thyroid nodules used in practice include fine needle biopsy (FNB) and core needle biopsy (CNB)
Taking the classification of resected specimens as the gold standard, CNB demonstrates a 95.93% sensitivity, 97.30% specificity, 62.07% accuracy, 99.81% positive predictive value (PPV), and 62.07% negative predictive value (NPV) for preoperative evaluation of thyroid nodules (Table 4)
Summary
Pathological diagnosis based on core needle biopsy (CNB) should be different from a resected specimen because it is difficult to apply the histological criteria established for resected specimens to CNB due to sampling limitations. The biopsy techniques for thyroid nodules used in practice include fine needle biopsy (FNB) and core needle biopsy (CNB). Several large single-center studies have shown no significant differences between FNB and CNB in terms of pain, tolerability, or complications [5, 6]. In this case, the advantage of CNB for obtaining a large amount of tissue and providing more information on histological structures is
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
